Differences Between Patients And Control Group - 1372 Words

A total of 100 subjects were included in this study, including 50 patients diagnosed as B-CLL, and 50 healthy subjects matched in age and sex as a control group. They were 75% male and 25% female for CLL group,and 70% male and 30% female for control group.The mean of age (in years) for B-CLL patients and healthy subjects was 63.65 ±9.23and 62.21 ±6.12, respectively. There were no statistically significant differences between patients and control group as regarding age and sex(P0.05) . According to the modified RAI staging system, the B-CLL patients in the present study were categorized into three risk groups the first group included 15 out of 50 (30%) patients with low risk, the second group included 15 (30%) patients with intermediate†¦show more content†¦The optimal CD 150 cut-off within the CLL population for overall survival was defined at 6% (13) Within this study there was 42 patients (84%) showing CD 150 expression ≠¥ 6% and 8 patients(16%) with CD 150 expression 6% . Patients with CD150 expression ≠¥ 6% had significantly longer OS (16 vs. 20 months) and significantly longer DFS (6 vs. 16.5 months) at 18 months compared to those with CD150 expression 6 %(P0.001) (Figs 1–4). These results suggest that CD 150 expression is greatly decreased in a subset of CLL patients characterized by an aggressive disease with a shorter DFS and a lower OS. Table 1 :Clinical and laboratory data of studied subjects: Variables Patients group Control group P.Value Hepatosplenomegaly(Present %) 35/50(70%) NA NA Lympadenopathy(Present %) 30/50 (60%) NA NA Hb level(gm/dl) (mean ±SD) 6.4-15.5(10.976+3.412) 11.9-14.8(13.213+0.939 0.001 Plts (Ãâ€"103/mm3) (mean ±SD) 50-309(142.920+ 70.884) 110-310(194.600 + 62.658) 0.001 WBCs (Ãâ€"103/mm3) (mean ±SD) 14.1-120 (59.7+42.8) 5–9.5 (7.06 ±1.46) 0.001 ALC(Ãâ€"103/mm3) (mean ±SD) 12–100 (41.68 ±23.32) 1–3 (1.75 ±0.613) 0.001 NA:not available ,Hb: hemoglobin, PLT:Show MoreRelatedCauses Of Acute Liver Failure1595 Words   |  7 Pagesliver failure is a syndrome characterized by development of altered mental status and coagulopathy in a patient within 8 weeks of onset of liver injury [1]. A large number of inflammatory markers have been implicated in causing the liver injury; and the massive hepatic insult that occur is believed mainly due to this tissue inflammation rather than the disease process per se. 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